Last update
5/21/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 26 Researches
8
USERS' SCORE
Good
Based on 4 Reviews
8.2
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B6 (as Pyridoxal-5-Phosphate)
1.5 mg
88%
Folate (400 mcg as (6S)-5-MTHF [from (6S)-5-Methyltetrahydrofolate Glucosamine Salt])
680 mcg DFE‡
170%
Vitamin B12 (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
9
We explored how vitamin B6 (VB6) supports heart recovery post-heart attack. In our study, we found that VB6 encourages angiogenesis, which is crucial for healing. Through experiments, we noticed that VB6 helps in cell migration and blood vessel formation by activating a specific protein that plays a key role in these processes. Additionally, long-term use of VB6 improved heart function in mice. While these findings are promising, it’s important to note that further research is necessary to fully understand VB6's effects in humans.
Read More
9
We looked into whether vitamin B-6 could help prevent heart failure with preserved ejection fraction (HFpEF) in a mouse model. By using a high-fat diet and other supplements, we created conditions for HFpEF and tested the effects of vitamin B-6 on cardiac function.
The results showed that co-administering vitamin B-6 improved heart function and reduced harmful phenotypic changes in heart macrophages. However, these benefits disappeared in mice lacking a specific protein called DOK3. Overall, vitamin B-6 appears to help mitigate HFpEF by supporting DOK3 signaling and inhibiting detrimental macrophage changes.
The results showed that co-administering vitamin B-6 improved heart function and reduced harmful phenotypic changes in heart macrophages. However, these benefits disappeared in mice lacking a specific protein called DOK3. Overall, vitamin B-6 appears to help mitigate HFpEF by supporting DOK3 signaling and inhibiting detrimental macrophage changes.
Read More
We conducted a case-control study to look into how maternal folic acid supplementation affects the risk of congenital heart disease (CHD) in children and whether genetic factors, specifically MTRR gene polymorphisms, play a role in this relationship.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
Read More
Most Useful Reviews
7.5
Regulates homocysteine levels
111 people found this helpful
This complex keeps my homocysteine at a safe level, benefiting heart health. It’s convenient to take as I don’t need multiple vitamins, and the price is reasonable. I’ve seen positive results in my test results.
Read More
7.5
B vitamin benefits
1 people found this helpful
My mother was prescribed this B vitamin complex to improve blood circulation and support heart health. It’s easy to take and seems effective, offering all necessary components in one product.
Read More
7.5
Essential for absorption
B12 is vital for everyone, not just vegetarians, especially when lowering homocysteine levels related to heart disease. This formulation features appropriate ingredients and dosages for optimal absorption.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 26 Researches
8
- All Researches
9
We explored how vitamin B6 (VB6) supports heart recovery post-heart attack. In our study, we found that VB6 encourages angiogenesis, which is crucial for healing. Through experiments, we noticed that VB6 helps in cell migration and blood vessel formation by activating a specific protein that plays a key role in these processes. Additionally, long-term use of VB6 improved heart function in mice. While these findings are promising, it’s important to note that further research is necessary to fully understand VB6's effects in humans.
Read More
9
We looked into whether vitamin B-6 could help prevent heart failure with preserved ejection fraction (HFpEF) in a mouse model. By using a high-fat diet and other supplements, we created conditions for HFpEF and tested the effects of vitamin B-6 on cardiac function.
The results showed that co-administering vitamin B-6 improved heart function and reduced harmful phenotypic changes in heart macrophages. However, these benefits disappeared in mice lacking a specific protein called DOK3. Overall, vitamin B-6 appears to help mitigate HFpEF by supporting DOK3 signaling and inhibiting detrimental macrophage changes.
The results showed that co-administering vitamin B-6 improved heart function and reduced harmful phenotypic changes in heart macrophages. However, these benefits disappeared in mice lacking a specific protein called DOK3. Overall, vitamin B-6 appears to help mitigate HFpEF by supporting DOK3 signaling and inhibiting detrimental macrophage changes.
Read More
9
We explored the effects of vitamin B6 (pyridoxine) on heart health, specifically looking at its protective qualities against angina provoked by vasopressin in a rat model. Vasopressin was administered to observe its impact on heart function, which included elevated stress on the heart indicated by changes on the electrocardiogram and increased cardiac enzymes.
The study found that when we gave rats pyridoxine in varying doses, it effectively reduced the ST elevation and heart rate changes caused by vasopressin. Notably, higher doses of pyridoxine (7 mg/kg) showed significant protective effects, outperforming both amlodipine and isosorbide. In addition, we observed that pyridoxine at these doses helped prevent cardiac tissue damage and improved heart structure.
Interestingly, while combining pyridoxine with amlodipine led to a trend of increased adverse cardiovascular events, the results underscored the potential of vitamin B6 in enhancing heart health. It appears vitamin B6 may work by improving certain functions in the body that support heart health, such as better blood vessel function and reduced levels of harmful substances.
Overall, our findings suggest that vitamin B6 could serve as a promising agent in preventing coronary heart disease, but more research is necessary to fully explore its benefits and practical applications in humans.
The study found that when we gave rats pyridoxine in varying doses, it effectively reduced the ST elevation and heart rate changes caused by vasopressin. Notably, higher doses of pyridoxine (7 mg/kg) showed significant protective effects, outperforming both amlodipine and isosorbide. In addition, we observed that pyridoxine at these doses helped prevent cardiac tissue damage and improved heart structure.
Interestingly, while combining pyridoxine with amlodipine led to a trend of increased adverse cardiovascular events, the results underscored the potential of vitamin B6 in enhancing heart health. It appears vitamin B6 may work by improving certain functions in the body that support heart health, such as better blood vessel function and reduced levels of harmful substances.
Overall, our findings suggest that vitamin B6 could serve as a promising agent in preventing coronary heart disease, but more research is necessary to fully explore its benefits and practical applications in humans.
Read More
9
We focused on how pyridoxamine, a form of vitamin B6, impacts heart health during treatment with doxorubicin, a common cancer drug. In an experimental setup with Sprague Dawley rats, we observed that those receiving doxorubicin experienced a decrease in heart function, specifically a reduced left ventricular ejection fraction, and an increase in heart volume.
Notably, when we added pyridoxamine to the treatment, these harmful effects were significantly lessened. The rats that took pyridoxamine alongside doxorubicin maintained better heart function compared to those who only received doxorubicin. This suggests that pyridoxamine acts as a protective agent for the heart, countering some of the negative impacts caused by doxorubicin.
However, we also investigated how doxorubicin and pyridoxamine affected breast cancer cells in the lab. While doxorubicin effectively reduced cancer cell viability and increased cell death, pyridoxamine didn’t change these outcomes. This indicates that while pyridoxamine can preserve heart health during chemotherapy, it doesn’t interfere with the cancer-fighting effects of doxorubicin.
Overall, this research highlights pyridoxamine's promising role as a cardioprotectant during cancer treatment, allowing for heart preservation without diminishing the effectiveness of anticancer therapies.
Notably, when we added pyridoxamine to the treatment, these harmful effects were significantly lessened. The rats that took pyridoxamine alongside doxorubicin maintained better heart function compared to those who only received doxorubicin. This suggests that pyridoxamine acts as a protective agent for the heart, countering some of the negative impacts caused by doxorubicin.
However, we also investigated how doxorubicin and pyridoxamine affected breast cancer cells in the lab. While doxorubicin effectively reduced cancer cell viability and increased cell death, pyridoxamine didn’t change these outcomes. This indicates that while pyridoxamine can preserve heart health during chemotherapy, it doesn’t interfere with the cancer-fighting effects of doxorubicin.
Overall, this research highlights pyridoxamine's promising role as a cardioprotectant during cancer treatment, allowing for heart preservation without diminishing the effectiveness of anticancer therapies.
Read More
We explored the potential benefits of a special compound that combines a vitamin B6 analog and another substance known for releasing nitric oxide. This research aimed to understand how this compound, known as 2-ethyl-3-hydroxy-6-methylpyridinium 2-nitroxysuccinate, could protect the heart during episodes of ischemia, which is when blood flow to the heart is reduced.
We conducted our study using a mouse model of myocardial ischemia, assessing how well this compound could reduce damage to heart cells. Our results showed that it had the ability to release nitric oxide, which is essential for heart health, while also combating oxidative stress—a harmful process that can worsen heart disease.
Furthermore, we noticed that this compound helped protect heart cells from damage caused by ischemia. The compound appeared to work by inhibiting reactive oxygen species, which can harm cells, and stabilizing mitochondrial function. This indicates that it may provide a dual action that both facilitates healthy blood flow and protects the heart from harm.
In summary, while our research focused on a vitamin B6 derivative, it ultimately suggests promising avenues for developing new treatments for cardiovascular diseases by harnessing the therapeutic potential of nitric oxide and reducing oxidative stress within heart tissue.
We conducted our study using a mouse model of myocardial ischemia, assessing how well this compound could reduce damage to heart cells. Our results showed that it had the ability to release nitric oxide, which is essential for heart health, while also combating oxidative stress—a harmful process that can worsen heart disease.
Furthermore, we noticed that this compound helped protect heart cells from damage caused by ischemia. The compound appeared to work by inhibiting reactive oxygen species, which can harm cells, and stabilizing mitochondrial function. This indicates that it may provide a dual action that both facilitates healthy blood flow and protects the heart from harm.
In summary, while our research focused on a vitamin B6 derivative, it ultimately suggests promising avenues for developing new treatments for cardiovascular diseases by harnessing the therapeutic potential of nitric oxide and reducing oxidative stress within heart tissue.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Regulates homocysteine levels
111 people found this helpful
This complex keeps my homocysteine at a safe level, benefiting heart health. It’s convenient to take as I don’t need multiple vitamins, and the price is reasonable. I’ve seen positive results in my test results.
Read More
7.5
B vitamin benefits
1 people found this helpful
My mother was prescribed this B vitamin complex to improve blood circulation and support heart health. It’s easy to take and seems effective, offering all necessary components in one product.
Read More
7.5
Essential for absorption
B12 is vital for everyone, not just vegetarians, especially when lowering homocysteine levels related to heart disease. This formulation features appropriate ingredients and dosages for optimal absorption.
Read More
6
Supports nervous system
This product aids in replenishing folic acid, which supports the nervous system and overall cell function, impacting brain and heart health positively. Methylfolate is quickly absorbed, with a pleasant taste. I’ve found great results, and the jar lasts well.
Read More
Frequently Asked Questions
9
We explored how vitamin B6 (VB6) supports heart recovery post-heart attack. In our study, we found that VB6 encourages angiogenesis, which is crucial for healing. Through experiments, we noticed that VB6 helps in cell migration and blood vessel formation by activating a specific protein that plays a key role in these processes. Additionally, long-term use of VB6 improved heart function in mice. While these findings are promising, it’s important to note that further research is necessary to fully understand VB6's effects in humans.
9
We looked into whether vitamin B-6 could help prevent heart failure with preserved ejection fraction (HFpEF) in a mouse model. By using a high-fat diet and other supplements, we created conditions for HFpEF and tested the effects of vitamin B-6 on cardiac function.
The results showed that co-administering vitamin B-6 improved heart function and reduced harmful phenotypic changes in heart macrophages. However, these benefits disappeared in mice lacking a specific protein called DOK3. Overall, vitamin B-6 appears to help mitigate HFpEF by supporting DOK3 signaling and inhibiting detrimental macrophage changes.
The results showed that co-administering vitamin B-6 improved heart function and reduced harmful phenotypic changes in heart macrophages. However, these benefits disappeared in mice lacking a specific protein called DOK3. Overall, vitamin B-6 appears to help mitigate HFpEF by supporting DOK3 signaling and inhibiting detrimental macrophage changes.
7
We conducted an insightful study to understand how plasma vitamin B6, specifically its active form known as pyridoxal 5'-phosphate (PLP), might influence the risk of coronary heart disease (CHD). Our focus was on evaluating both overall effects and any notable differences between men and women.
In our research, we included 429 patients with diagnosed CHD and an equal number of controls, all matched for age, sex, and time of operation. By examining plasma PLP levels through sophisticated testing methods, we made some intriguing discoveries.
While we observed that higher levels of PLP were generally linked to a lower risk of CHD, this association strongly favored women. Specifically, each increase of 1 ng/mL in PLP was correlated with a 28% reduced risk of CHD in the overall group, and in women, this translated to a significant protection (odds ratio of 0.63). However, the same could not be said for men, where the results were not as clear-cut.
These findings reveal a noteworthy trend, suggesting that vitamin B6 may play a critical role in heart health for women, a connection that deserves further exploration. We believe this opens new avenues for understanding heart disease, especially among different genders.
In our research, we included 429 patients with diagnosed CHD and an equal number of controls, all matched for age, sex, and time of operation. By examining plasma PLP levels through sophisticated testing methods, we made some intriguing discoveries.
While we observed that higher levels of PLP were generally linked to a lower risk of CHD, this association strongly favored women. Specifically, each increase of 1 ng/mL in PLP was correlated with a 28% reduced risk of CHD in the overall group, and in women, this translated to a significant protection (odds ratio of 0.63). However, the same could not be said for men, where the results were not as clear-cut.
These findings reveal a noteworthy trend, suggesting that vitamin B6 may play a critical role in heart health for women, a connection that deserves further exploration. We believe this opens new avenues for understanding heart disease, especially among different genders.
8
We explored the role of vitamin B6 in heart disease, particularly its potential benefits for arrhythmias and overall cardiac function. The study reviewed existing literature, highlighting how a deficiency in vitamin B6 can lead to increased calcium entry in heart cells and contribute to issues like cardiac dysfunction.
We observed that the active form of vitamin B6, known as pyridoxal 5'-phosphate, can help reduce arrhythmias caused by myocardial infarction and improve heart function. This connection suggests that vitamin B6 may play a preventive role in heart disease rather than being a therapeutic remedy after issues arise.
However, while findings related to vitamin B6 are promising, they are part of a broader conversation about the complexities of cardiovascular disorders and the overall effectiveness of vitamins. Overall, the evidence on vitamin B6’s role in heart disease is valuable but not conclusive enough to establish a standalone treatment.
We observed that the active form of vitamin B6, known as pyridoxal 5'-phosphate, can help reduce arrhythmias caused by myocardial infarction and improve heart function. This connection suggests that vitamin B6 may play a preventive role in heart disease rather than being a therapeutic remedy after issues arise.
However, while findings related to vitamin B6 are promising, they are part of a broader conversation about the complexities of cardiovascular disorders and the overall effectiveness of vitamins. Overall, the evidence on vitamin B6’s role in heart disease is valuable but not conclusive enough to establish a standalone treatment.
References
- Wang XQ, Yin S, Wang QW, Bai WW, Tan RH, et al. Vitamin B6 allosterically activates AMPK to promote postischemic angiogenesis in mice. Eur J Pharmacol. 2025;993:177413. 10.1016/j.ejphar.2025.177413
- Ma L, Zeng L, Wang X. MTHFR C677T gene polymorphism in patients with coronary heart disease and hypertension treated with enalapril and folic acid: implications for prognosis. Cell Mol Biol (Noisy-le-grand). 2024;70:142. 10.14715/cmb/2024.70.9.20
- Song JW, Zhang ZS, Chen L, Wang QW, Xu JY, et al. Vitamin B-6 Prevents Heart Failure with Preserved Ejection Fraction Through Downstream of Kinase 3 in a Mouse Model. J Nutr. 2024;154:3031. 10.1016/j.tjnut.2024.08.006
- Xu W, Cao Y, Stephens SB, Arredondo MJ, Chen Y, et al. Folate as a potential treatment for lethal ventricular arrhythmias in TANGO2-deficiency disorder. JCI Insight. 2024;9. 10.1172/jci.insight.171005
- Morimoto J, Satogami K, Naraoka T, Taruya A, Tanaka A. Long-Term Maintenance of Normal Serum Vitamin B Levels Is Associated with Better Outcomes in Patients with Heart Failure. Int Heart J. 2024;65:458. 10.1536/ihj.23-550
- Al-Khawlani MA, Al-Madhagi WM, Sabati AM, ALomaisi SAMA, Al-Najar M. Protective effects of pyridoxine, amlodipine, and their combination in a vasopressin-induced angina model in rats. Naunyn Schmiedebergs Arch Pharmacol. 2025. 10.1007/s00210-025-03905-6
- Li B, Hu M, Ma Y, Sun X, Wu D, et al. Association between Vitamin E, Vitamin B6, and Vitamin B12 with coronary heart disease. Sci Rep. 2024;14:19960. 10.1038/s41598-024-68413-8
- Agraib LM, Al-Shami I, Alkhatib B, Hasan H. The impact of energy releasing B-vitamin intake on indices of obesity and cardiac function: a cross-sectional study. F1000Res. 2023;12:1382. PubMed
- D'Haese S, Claes L, Jaeken E, Deluyker D, Evens L, et al. Pyridoxamine Alleviates Cardiac Fibrosis and Oxidative Stress in Western Diet-Induced Prediabetic Rats. Int J Mol Sci. 2024;25. 10.3390/ijms25158508
- Haesen S, Verghote E, Heeren E, Wolfs E, Deluyker D, et al. Pyridoxamine Attenuates Doxorubicin-Induced Cardiomyopathy without Affecting Its Antitumor Effect on Rat Mammary Tumor Cells. Cells. 2024;13. 10.3390/cells13020120
- Faingold II, Smolina AV, Soldatova YV, Poletaeva DA, Balakina AA, et al. Cardioprotective Effect of 2-Ethyl-3-Hydroxy-6-Methylpyridinium 2-Nitroxysuccinate Against Adrenaline/Hydrocortisone-Induced Myocardial Ischemia in Mice: Modulation of Free-Radical Processes in Biomembranes and Monoamine Oxidase A Activity. Cell Biochem Biophys. 2024;82:235. 10.1007/s12013-023-01203-7
- Sun RL, Wang HH, Gui ZC, Lin LB, Fan JX, et al. Protective effect of vitamin B against doxorubicin-induced cardiotoxicity by modulating NHE1 expression. J Biochem Mol Toxicol. 2023;37:e23403. 10.1002/jbt.23403
- Hanssen NMJ, Tikellis C, Pickering RJ, Dragoljevic D, Lee MKS, et al. Pyridoxamine prevents increased atherosclerosis by intermittent methylglyoxal spikes in the aortic arches of ApoE mice. Biomed Pharmacother. 2023;158:114211. 10.1016/j.biopha.2022.114211
- Bajic Z, Sobot T, Skrbic R, Stojiljkovic MP, Ponorac N, et al. Homocysteine, Vitamins B6 and Folic Acid in Experimental Models of Myocardial Infarction and Heart Failure-How Strong Is That Link?. Biomolecules. 2022;12. 10.3390/biom12040536
- Hu L, Li Y, Liu Z, Fan F, Xu B, et al. Association of Plasma Vitamin B6 With Coronary Heart Disease in Patients Undergoing Diagnostic Coronary Angiography: New Insight on Sex Differences. Front Cardiovasc Med. 2021;8:789669. 10.3389/fcvm.2021.789669
- Huang TH, Chang HH, Guo YR, Chang WC, Chen YF. Vitamin B Mitigates Thoracic Aortic Dilation in Marfan Syndrome Mice by Restoring the Canonical TGF-β Pathway. Int J Mol Sci. 2021;22. 10.3390/ijms222111737
- Shah AK, Dhalla NS. Effectiveness of Some Vitamins in the Prevention of Cardiovascular Disease: A Narrative Review. Front Physiol. 2021;12:729255. 10.3389/fphys.2021.729255
- Evens L, Beliën H, D'Haese S, Haesen S, Verboven M, et al. Combinational Therapy of Cardiac Atrial Appendage Stem Cells and Pyridoxamine: The Road to Cardiac Repair?. Int J Mol Sci. 2021;22. 10.3390/ijms22179266
- Kumrungsee T, Yanaka N, Suda T, Kato N. Emerging cardioprotective mechanisms of vitamin B6: a narrative review. Eur J Nutr. 2022;61:605. 10.1007/s00394-021-02665-2
- Ruan X, Shang W, Lu J, Li Z, Yang J, et al. Maternal multivitamin supplementation mitigates the risk of fetal congenital heart disease associated with high indoor total volatile organic compounds exposure in east china: a case-control study. Environ Health. 2024;23:110. 10.1186/s12940-024-01150-7
- Li L, Ou J, Chen Y, Chen Q, Luo M, et al. Association of maternal folic acid supplementation and offspring MTRR gene polymorphism with congenital heart disease: a hospital-based case-control study in Han population. J Health Popul Nutr. 2024;43:220. 10.1186/s41043-024-00699-w
- Qu Y, Liu X, Lin S, Bloom MS, Wang X, et al. Maternal Serum Folate During Pregnancy and Congenital Heart Disease in Offspring. JAMA Netw Open. 2024;7:e2438747. 10.1001/jamanetworkopen.2024.38747
- Hjalmarsson C, Backelin C, Thoren A, Bergh N, Sloan JL, et al. Severe heart failure in a unique case of cobalamin-C-deficiency resolved with LVAD implantation and subsequent heart transplantation. Mol Genet Metab Rep. 2024;39:101089. 10.1016/j.ymgmr.2024.101089
- Domínguez-López I, Kovatcheva M, Casas R, Toledo E, Fitó M, et al. Higher circulating vitamin B12 is associated with lower levels of inflammatory markers in individuals at high cardiovascular risk and in naturally aged mice. J Sci Food Agric. 2024;104:875. 10.1002/jsfa.12976
- Qin Y, Shi Y, Yu Q, Yang S, Wang Y, et al. Vitamin B12 alleviates myocardial ischemia/reperfusion injury via the SIRT3/AMPK signaling pathway. Biomed Pharmacother. 2023;163:114761. 10.1016/j.biopha.2023.114761
- Mohan A, Kumar R, Kumar V, Yadav M. Homocysteine, Vitamin B12 and Folate Level: Possible Risk Factors in the Progression of Chronic Heart and Kidney Disorders. Curr Cardiol Rev. 2023;19:e090223213539. 10.2174/1573403X19666230209111854
